He later appeared in Man-Thing, Feed, and in the Australian mini-series The Incredible Journey of Mary Bryant, for which he was nominated as Best Lead Actor in Television from the Australian Film Institute Awards in 2005 and as Most Outstanding Actor in a Drama Series from the Logie Awards in 2006.
O'Loughlin joined the cast of The Shield in 2007 as Detective Kevin Hiatt, the newest member of the strike team.
150, reflects on the 149 episodes leading up to it and teases his current timetable for turning in Mc Garrett’s badge and gun. And if you don’t give up, what does that look like?Despite being the highest rated show in its Friday evening slot In April 2009, he guest-starred in an episode of Criminal Minds in the Season Four episode, "The Big Wheel", as an OCD-ridden serial killer, Vincent Rowlings.In December 2009 CBS pulled Three Rivers from its schedule.Looking back over these first 150 episodes, what’s been the most difficult scene for you to do physically? But the physical exhaustion of working with injury and working huge hours day after day, year after year…., entitled “Ka makuahine a me ke keikikane” (which is Hawaiian for “Mother and Son”), Five-0 must team up to free Steve Mc Garrett’s (Alex O’Loughlin) mother, Doris (Christine Lahti), when Catherine (Michelle Borth) informs them that she’s been captured. That’s a big milestone that very few TV series ever get to anymore.After graduating from NIDA (National Institute of Dramatic Arts), he began his career in Australian television and film productions.