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Over the course of its many years on the air, the show's titular lead, Meredith Grey (Ellen Pompeo), has evolved from a hard-partying surgical intern to a surgeon and widowed mother of three, almost in real time.

Along with Meredith, the show has evolved—from disease-of-the-week drama to mandatory viewing for the millions of fans who tune in each week for the blood, tears, nailbiting surgeries, and endless on-call room hook-ups.

After a drunken one-night stand, she stumbles to her first day of a prestigious medical residency, and discovers that last night's bedmate is her boss, Derek Shepherd (Patrick Dempsey)—and he's married.

Her new BFF, intern Cristina Yang (Sandra Oh), also starts a relationship with her boss, surgeon Preston Burke (Isaiah Washington).

To help you prepare for the new season, here is a speedy catch-up guide: everything you need to know about all 12 seasons of Meet Dr Meredith Grey, a "dark and twisty," tequila-loving medical resident with serious mommy issues.as Mc Dreamy’s wife and showed up in a shocking entrance just as the romance between Meredith and Derek was starting to take flight.When reflecting on this pivotal moment, Walsh commented,”I got more calls and attention from that 60-second scene than anything in my career before. ” Walsh continued, “Everyone hated me, but at that time there was no Twitter.There were chat rooms, but I never really went on them.I kind of liked being the Wicked Witch from the East. Shonda [Rhime’s] really gifted at flipping every character that’s seemingly awful. So when she discovers that she's pregnant, Bridget hasn't a clue which man is the father.

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